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Environmental novelty elicits a later theta phase of firing in CA1 but not subiculum
Author(s) -
Lever Colin,
Burton Stephen,
Jeewajee Ali,
Wills Thomas J.,
Cacucci Francesca,
Burgess Neil,
O'Keefe John
Publication year - 2010
Publication title -
hippocampus
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.767
H-Index - 155
eISSN - 1098-1063
pISSN - 1050-9631
DOI - 10.1002/hipo.20671
Subject(s) - subiculum , neuroscience , novelty , hippocampal formation , hippocampus , psychology , chemistry , dentate gyrus , social psychology
The mechanism supporting the role of the hippocampal formation in novelty detection remains controversial. A comparator function has been variously ascribed to CA1 or subiculum, whereas the theta rhythm has been suggested to separate neural firing into encoding and retrieval phases. We investigated theta phase of firing in principal cells in subiculum and CA1 as rats foraged in familiar and novel environments. We found that the preferred theta phase of firing in CA1, but not subiculum, was shifted to a later phase of the theta cycle during environmental novelty. Furthermore, the amount of phase shift elicited by environmental change correlated with the extent of place cell remapping in CA1. Our results support a relationship between theta phase and novelty‐induced plasticity in CA1. © 2009 Wiley‐Liss, Inc.