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Genetic ablation of tenascin‐C expression leads to abnormal hippocampal CA1 structure and electrical activity in vivo
Author(s) -
Gurevicius Kestutis,
Kuang Fang,
Stoenica Luminita,
Irintchev Andrey,
Gureviciene Irina,
Dityatev Alexander,
Schachner Melitta,
Tanila Heikki
Publication year - 2009
Publication title -
hippocampus
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.767
H-Index - 155
eISSN - 1098-1063
pISSN - 1050-9631
DOI - 10.1002/hipo.20585
Subject(s) - dentate gyrus , hippocampal formation , neuroscience , hippocampus , perforant path , long term potentiation , synaptic plasticity , chemistry , entorhinal cortex , synaptogenesis , biology , biochemistry , receptor
Abstract Despite evidence that the extracellular matrix glycoprotein tenascin‐C (TNC) is implicated in brain development and plasticity, its roles in the intact adult brain are unknown. Here we report that spontaneous local field potential (LFP) activity in freely moving adult TNC‐deficient mice is abnormal. The power of cortical and hippocampal theta and gamma oscillations was enhanced in comparison to wild‐type mice. The alteration in hippocampal gamma rhythm was subfield specific, such that CA1 gamma was accentuated while dentate gyrus gamma was normal. Similar to LFP, synaptic transmission and plasticity at perforant path synapses in the dentate gyrus were unaffected by the mutation. Morphological analyses revealed a subfield‐specific reduction in the CA1 volume and a reduction in the numbers of somatostatin‐positive interneurons in the hippocampus as potential structural substrates of the observed functional aberrations. These findings indicate a role for tenascin‐C in structural organization of the CA1 hippocampal subfield and in shaping neural activity. © 2009 Wiley‐Liss, Inc.