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Ventral hippocampal involvement in temporal order, but not recognition, memory for spatial information
Author(s) -
Howland John G.,
Harrison Rebecca A.,
Hannesson Darren K.,
Phillips Anthony G.
Publication year - 2008
Publication title -
hippocampus
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.767
H-Index - 155
eISSN - 1098-1063
pISSN - 1050-9631
DOI - 10.1002/hipo.20396
Subject(s) - hippocampus , neuroscience , spatial memory , hippocampal formation , psychology , recognition memory , prefrontal cortex , dorsum , spatial analysis , working memory , cognition , biology , anatomy , mathematics , statistics
The hippocampus is critical for spatial memory. Recently, subregional differences in the function of hippocampus have been described in a number of behavioral tasks. The present experiments assessed the effects of reversibly lesioning either the dorsal (dHip) or ventral hippocampus (vHip) on spontaneous tests of spatial recognition and temporal order memory. We report that although the dHip is necessary for spatial recognition memory (RM) (distinguishing a novel from a familiar spatial location), the vHip is involved in temporal order memory (the capacity to distinguish between two spatial locations visited at different points in time), but not RM. These findings and others are consistent with the hypothesis that temporal order memory is supported by an integrated circuit of limbic areas including the vHip and the medial prefrontal cortex. © 2007 Wiley‐Liss, Inc.