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Inhibition of mRNA synthesis in the hippocampus impairs consolidation and reconsolidation of spatial memory
Author(s) -
Da Silva Weber C.,
Bonini Juliana S.,
Bevilaqua Lia R.M.,
Medina Jorge H.,
Izquierdo Iván,
Cammarota Martín
Publication year - 2008
Publication title -
hippocampus
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.767
H-Index - 155
eISSN - 1098-1063
pISSN - 1050-9631
DOI - 10.1002/hipo.20362
Subject(s) - memory consolidation , neuroscience , hippocampal formation , hippocampus , engram , psychology , mnemonic , immediate early gene , consolidation (business) , long term potentiation , chemistry , gene expression , cognitive psychology , gene , biochemistry , accounting , business , receptor
Using two different mRNA synthesis inhibitors, we show that blockade of hippocampal gene expression during restricted posttraining or postretrieval time windows hinders retention of long‐term spatial memory for the Morris water maze task, without affecting short‐term memory, nonspatial learning, or the functionality of the hippocampus. Our results indicate that spatial memory consolidation induces the activation of the hippocampal transcriptional machinery and suggest the existence of a gene expression‐dependent reconsolidation process that operates in the dorsal hippocampus at the moment of retrieval to stabilize the reactivated mnemonic trace. © 2007 Wiley‐Liss, Inc.