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Polyribosomes are increased in spines of CA1 dendrites 2 h after the induction of LTP in mature rat hippocampal slices
Author(s) -
Bourne Jennifer N.,
Sorra Karin E.,
Hurlburt Jamie,
Harris Kristen M.
Publication year - 2007
Publication title -
hippocampus
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.767
H-Index - 155
eISSN - 1098-1063
pISSN - 1050-9631
DOI - 10.1002/hipo.20238
Subject(s) - long term potentiation , dendritic spine , hippocampal formation , polysome , postsynaptic potential , neuroscience , ltp induction , chemistry , stimulation , hippocampus , dendrite (mathematics) , biology , biochemistry , rna , receptor , ribosome , geometry , mathematics , gene
Abstract Enduring long‐term potentiation (LTP) requires immediate protein synthesis, hence we assessed whether more polyribosomes are present in dendritic spines of mature hippocampal dendrites after the induction of LTP. Reconstructions from serial section transmission electron microscopy (sSTEM) revealed more dendritic polyribosomes 2 h posttetanus, relative to low‐frequency stimulation (LFS). Polyribosomes were present in spines of all shapes with larger postsynaptic densities after 2 h, suggesting a coordinated local protein synthesis among many synapses to replenish proteins utilized during an earlier phase of LTP. © 2006 Wiley‐Liss, Inc.