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Dynamic mapping of normal human hippocampal development
Author(s) -
Gogtay Nitin,
Nugent Tom F.,
Herman David H.,
Ordonez Anna,
Greenstein Deanna,
Hayashi Kiralee M.,
Clasen Liv,
Toga Arthur W.,
Giedd Jay N.,
Rapoport Judith L.,
Thompson Paul M.
Publication year - 2006
Publication title -
hippocampus
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.767
H-Index - 155
eISSN - 1098-1063
pISSN - 1050-9631
DOI - 10.1002/hipo.20193
Subject(s) - hippocampal formation , hippocampus , neuroscience , human brain , psychology , brain mapping , magnetic resonance imaging , functional magnetic resonance imaging , medicine , radiology
The hippocampus, which plays an important role in memory functions and emotional responses, has distinct subregions subserving different functions. Because the volume and shape of the hippocampus are altered in many neuropsychiatric disorders, it is important to understand the trajectory of normal hippocampal development. We present the first dynamic maps to reveal the anatomical sequence of normal human hippocampal development. A novel hippocampal mapping technique was applied to a database of prospectively obtained brain magnetic resonance imaging (MRI) scans (100 scans in 31 children and adolescents), scanned every 2 yr for 6–10 yr between ages 4 and 25. Our results establish that the structural development of the human hippocampus is remarkably heterogeneous, with significant differences between posterior (increase over time) and anterior (loss over time) subregions. These distinct developmental trajectories of hippocampal subregions may parallel differences in their functional development. Published 2006 Wiley‐Liss, Inc.