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Protein synthesis‐dependent LTP in isolated dendrites of CA1 pyramidal cells
Author(s) -
Cracco Joan B.,
Serrano Peter,
Moskowitz Shaye I.,
Bergold Peter J.,
Sacktor Todd Charlton
Publication year - 2005
Publication title -
hippocampus
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.767
H-Index - 155
eISSN - 1098-1063
pISSN - 1050-9631
DOI - 10.1002/hipo.20078
Subject(s) - long term potentiation , neuroscience , chemistry , hippocampus , psychology , biochemistry , receptor
Local dendritic protein synthesis provides a mechanism by which the effects of gene expression can be spatially restricted within synaptodendritic compartments of neurons. In the present study, we show that long‐term potentiation (LTP), induced by two strong tetanic trains, can be produced in isolated CA1 apical dendrites and that new protein synthesis is critical for this dendritic LTP. LTP in isolated dendrites is also blocked by rapamycin, an inhibitor of growth‐related protein synthesis, similar to that observed for LTP in the intact hippocampal slice. These results show that increased dendritic translation of proteins is a critical molecular mechanism for hippocampal LTP. © 2005 Wiley‐Liss, Inc.