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Long‐term potentiation as a substrate for memory: Evidence from studies of amygdaloid plasticity and Pavlovian fear conditioning
Author(s) -
Goosens Ki A.,
Maren Stephen
Publication year - 2002
Publication title -
hippocampus
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.767
H-Index - 155
eISSN - 1098-1063
pISSN - 1050-9631
DOI - 10.1002/hipo.10099
Subject(s) - long term potentiation , neuroscience , fear conditioning , psychology , associative learning , conditioning , classical conditioning , fear processing in the brain , memory consolidation , synaptic plasticity , cognitive psychology , amygdala , hippocampus , biology , biochemistry , statistics , receptor , mathematics
Recent reports have raised concerns about the ability of long‐term potentiation (LTP) to account for associative learning and memory. In this paper, we review the many mechanistic similarities between one form of associative learning, Pavlovian fear conditioning, and amygdaloid LTP. We then address many of the criticisms levied against LTP within the framework of fear conditioning. We believe that many of the apparent discrepancies between LTP and behavior can be generally accounted for by a failure to appreciate that learned behavior is supported by multiple synapses in an extensive network of brain structures. We conclude that LTP remains a viable substrate for memory. Hippocampus 2002;12:592–599. © 2002 Wiley‐Liss, Inc.