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Single neuron burst firing in the human hippocampus during sleep
Author(s) -
Staba Richard J.,
Wilson Charles L.,
Fried Itzhak,
Engel Jerome
Publication year - 2002
Publication title -
hippocampus
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.767
H-Index - 155
eISSN - 1098-1063
pISSN - 1050-9631
DOI - 10.1002/hipo.10026
Subject(s) - hippocampal formation , neuroscience , hippocampus , memory consolidation , wakefulness , sleep (system call) , neuron , slow wave sleep , neuroscience of sleep , psychology , bursting , population , electroencephalography , medicine , environmental health , computer science , operating system
Although there are numerous non‐primate studies of the single neuron correlates of sleep‐related hippocampal EEG patterns, very limited hippocampal neuronal data are available for correlation with human sleep. We recorded human hippocampal single neuron activity in subjects implanted with depth electrodes required for medical diagnosis and quantitatively evaluated discharge activity from each neuron during episodes of wakefulness (Aw), combined stage 3 and 4 slow‐wave sleep (SWS), and rapid eye movement (REM) sleep. The mean firing rate of the population of single neurons was significantly higher during SWS and Aw compared with REM sleep ( p = 0.002; p < 0.0001). In addition, burst firing was significantly greater during SWS compared with Aw ( p = 0.001) and REM sleep ( p < 0.0001). The synchronized state of SWS and associated high‐frequency burst discharge found in human hippocampus may subserve functions similar to those reported in non‐primate hippocampus that require burst firing to induce synaptic modifications in hippocampal circuitry and in hippocampal projections to neocortical targets that participate in memory consolidation. Hippocampus 2002;12:724–734. © 2002 Wiley‐Liss, Inc.