Open AccessHepatic Stellate Cell Regulation of Liver Regeneration and Repair
Author(s) -
Kitto Laura J.,
Henderson Neil C.
Publication year - 2021
Publication title -
hepatology communications
Language(s) - English
Resource type - Journals
ISSN - 2471-254X
DOI - 10.1002/hep4.1628
Subject(s) - mesenchyme , regeneration (biology) , liver regeneration , mesenchymal stem cell , hepatic stellate cell , biology , context (archaeology) , microbiology and biotechnology , organoid , regenerative medicine , pathology , bioinformatics , medicine , stem cell , endocrinology , paleontology
The hepatic mesenchyme has been studied extensively in the context of liver fibrosis; however, much less is known regarding the role of mesenchymal cells during liver regeneration. Single‐cell genomics approaches have recently uncovered both spatial and functional zonation of the hepatic mesenchyme in homeostasis and following liver injury. Here we discuss how the use of preclinical models are helping to shape our understanding of the role of the mesenchyme during liver regeneration, and how these approaches should facilitate the precise identification of highly targeted, pro‐regenerative therapies for patients with liver disease.