Open AccessALT Levels for Asians With Metabolic Diseases: A Meta‐analysis of 86 Studies With Individual Patient Data Validation
Author(s) -
Huang Daniel Q.,
Yeo Yee Hui,
Tan Eunice,
Takahashi Hirokazu,
Yasuda Satoshi,
Saruwatari Junji,
Tanaka Kenichi,
Oniki Kentaro,
Kam Leslie Y.,
Muthiah Mark D.,
Hyogo Hideyuki,
Ono Masafumi,
Barnett Scott D.,
Li Jie,
Zou Biyao,
Fung James,
Lee TengYu,
Wong Vincent WaiSun,
Yuen ManFung,
Dan Yock Young,
Lim Seng Gee,
Cheung Ramsey,
Toyoda Hidenori,
Eguchi Yuichiro,
Nguyen Mindie H.
Publication year - 2020
Publication title -
hepatology communications
Language(s) - English
Resource type - Journals
ISSN - 2471-254X
DOI - 10.1002/hep4.1593
Subject(s) - medicine , overweight , percentile , meta analysis , alanine aminotransferase , random effects model , nonalcoholic fatty liver disease , obesity , demography , fatty liver , gastroenterology , disease , statistics , mathematics , sociology
In this systematic review and meta‐analysis of 86 studies and 526,641 individuals without viral hepatitis and hepatic steatosis, the ALT upper threshold was 39 in overweight patients versus 28 in normal‐weight individuals, and 36 in diabetics versus 33 in nondiabetics. These findings were validated in a multicenter cohort of 6,058 patients. Diabetic and overweight patients with ALT values within these thresholds can potentially avoid extensive and possibly harmful invasive investigations after excluding viral hepatitis and nonalcoholic fatty liver disease. However, close monitoring and management of metabolic factors are required.