Open AccessExposure to sub‐parts per million levels of vinyl chloride can increase the risk of developing liver injury
Author(s) -
Fujiwara Ryoichi
Publication year - 2018
Publication title -
hepatology communications
Language(s) - English
Resource type - Journals
ISSN - 2471-254X
DOI - 10.1002/hep4.1169
Subject(s) - vinyl chloride , chemistry , carcinogen , liver injury , adduct , metabolism , chloride , biochemistry , organic chemistry , biology , pharmacology , polymer , copolymer
Vinyl chloride is primarily metabolized in the liver to multiple metabolites. Chloroethylene oxide and chloroacetaldehyde are the reactive intermediate metabolites and their formation of DNA and protein adducts is closely related to the carcinogenic property of vinyl chloride. Meanwhile, 2‐chloroethanol, in addition to vinyl chloride, is involved in the enhanced susceptibility to liver injury by dysregulating glucose metabolism and inducing mitochondrial damage.