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Prostaglandin E 1 protects against liver injury induced by Escherichia coli infection via a dominant th2‐like response of liver T cells in mice
Author(s) -
Mokuno Yasuji,
Takano Manabu,
Matsuguchi Tetsuya,
Nishimura Hitoshi,
Washizu Junji,
Naiki Yoshikazu,
Nimura Yuji,
Yoshikai Yasunobu
Publication year - 1999
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.510300606
Subject(s) - liver injury , prostaglandin , lipopolysaccharide , prostaglandin e2 , prostaglandin e , chemistry , monoclonal antibody , medicine , endocrinology , antibody , pharmacology , immunology , biology
Prostaglandin E series (PGEs) are known to protect against lipopolysaccharide (LPS)‐induced liver injury by down‐regulating the production of inflammatory cytokines. We show here a novel mechanism whereby prostaglandin E 1 protects mice against liver injury after Escherichia coli infection. Prostaglandin E 1 administration suppressed circulating interleukin 12 (IL‐12) levels but increased the IL‐10 production after E. coli challenge. Furthermore, prostaglandin E 1 ‐α‐cyclodextrin (PGE 1 ) shifted the Th1/Th2 balance of CD3 intermediate IL‐2Rβ + T cells in the liver to a dominant Th2‐like response. Neutralization of endogenous IL‐4 by administration of anti–IL‐4 monoclonal antibody (mAb) diminished the inhibitory effect of prostaglandin E 1 on liver injury after E. coli challenge. These results suggested that the Th2‐like response of liver T cells may be at least partly involved in the mechanism whereby prostaglandin E 1 protects against E. coli ‐induced liver injury.