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Changing blood into liver: Adding further intrigue to the hepatic stem cell story
Author(s) -
Strain Alastair J.
Publication year - 1999
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.510300438
Subject(s) - bone marrow , stem cell , biology , hepatocyte , liver regeneration , haematopoiesis , bone marrow stem cell , pathology , adult stem cell , stem cell transplantation for articular cartilage repair , mesenchymal stem cell , regeneration (biology) , microbiology and biotechnology , endothelial stem cell , immunology , medicine , biochemistry , in vitro
Bone marrow stem cells develop into hematopoietic and mesenchymal lineages but have not been known to participate in production of hepatocytes, biliary cells, or oval cells during liver regeneration. Cross‐sex or cross‐stain bone marrow and whole liver transplantation were used to trace the origin of the repopulating liver cells. Transplanted rats were treated with 2‐acetylaminofluorene, to block hepatocyte proliferation, and then hepatic injury, to induce oval cell proliferation. Markers for Y chromosome, dipeptidyl peptidase IV enzyme, and L21‐6 antigen were used to identify liver cells of bone marrow origin. From these cells, a proportion of the regenerated hepatic cells were shown to be donor‐derived. Thus, a stem cell associated with the bone marrow has epithelial cell lineage capability.