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Influence of human immunodeficiency virus infection on chronic hepatitis B in homosexual men
Author(s) -
Colin JeanFrançois,
CazalsHatem Dominique,
Loriot Marie Anne,
MartinotPeignoux Michèle,
Pham Bach Nga,
Auperin Anne,
Degott Claude,
Benhamou JeanPierre,
Erlinger Serge,
Valla Dominique,
Marcellin Patrick
Publication year - 1999
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.510290447
Subject(s) - medicine , hepatitis b virus , cirrhosis , alanine transaminase , hepatitis b , immunology , liver function , gastroenterology , hepatitis , liver function tests , virus
The aim of this study was to assess the influence of human immunodeficiency virus (HIV) infection on chronic hepatitis B. In a series of 132 (65 anti‐HIV positive) homosexual non–drug addicted men with chronic hepatitis B, the liver function was assessed with biochemical tests; the degree of hepatitis B virus (HBV) replication was assessed with serum HBV DNA level and with immunoperoxidase staining of hepatitis B core (HBc) antigen on liver specimens; and the severity of liver lesions was assessed with an histology activity index. Anti‐HIV–positive and anti‐HIV–negative patients were not different for serum aspartate transaminase activity, bilirubin, prothrombin, and histology activity index. Anti‐HIV–positive patients had lower serum alanine transaminase activity levels ( P = .0001), lower serum albumin levels ( P = .0009), and higher serum HBV DNA levels ( P = .01). There was a higher prevalence of cirrhosis in anti‐HIV–positive patients ( P = .04). In homosexual men with chronic hepatitis B, HIV infection is associated with a higher level of HBV replication and a higher risk for cirrhosis without increased liver necrotico‐inflammatory process.