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Dexamethasone inhibits the proliferation of hepatocytes and oval cells but not bile duct cells in rat liver
Author(s) -
Nagy Peter,
Kiss Andras,
Schnur Janos,
Thorgeirsson Snorri S.
Publication year - 1998
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.510280220
Subject(s) - dexamethasone , bile duct , medicine , cell growth , endocrinology , tumor necrosis factor alpha , hepatocyte , interleukin , liver regeneration , biology , cytokine , chemistry , cancer research , microbiology and biotechnology , in vitro , regeneration (biology) , biochemistry
Recent advances have implicated the importance of tumor necrosis factor (TNF) and interleukin 6 (IL‐6) in the regulation of liver growth. Therefore, we studied how dexamethasone, a well‐known inhibitor of these cytokines, influences the proliferation of different hepatic cell populations. As we expected, dexamethasone pretreatment suppressed the expression of both TNF and IL‐6 after partial hepatectomy and significantly reduced the proliferative response of the hepatocytes. Furthermore, the proliferative response of hepatocytes could be rescued by IL‐6 administration. Dexamethasone also severely diminished the induction and expansion of oval cells induced by the 2‐acetylaminofluorene/partial hepatectomy (AAF/PH) protocol but did not have any effect on the proliferation of the bile duct cells stimulated by bile duct ligation. The differential inhibition of these two morphologically very similar cell types may be used to characterize divergent regulatory mechanisms responsible for the proliferative response of oval cells and adult bile epithelial cells.