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Hepatic venous hemoglobin oxygen saturation predicts regenerative status of remnant liver after partial hepatectomy in rats
Author(s) -
Yoshioka Shigeru,
Miyazaki Masaru,
Shimizu Hiroaki,
Ito Hiroshi,
Nakagawa Koji,
Ambiru Satoshi,
Nakajima Nobuyuki,
Fukuda Yasuichiro
Publication year - 1998
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.510270522
Subject(s) - hepatectomy , liver regeneration , energy charge , medicine , oxygen , hemoglobin , oxidative phosphorylation , endocrinology , chemistry , regeneration (biology) , biology , surgery , biochemistry , receptor , organic chemistry , resection , adenylate kinase , microbiology and biotechnology
This study was designed to evaluate the use of hepatic venous hemoglobin oxygen saturation (Shv o 2 ) as an indicator of hepatic oxygen supply‐demand relation and also regenerative status of the liver after partial hepatectomy in rats. We assessed the Shv o 2 levels for 7 days, as well as hepatic hemodynamics, oxygen consumption, DNA synthesis and energy charge of the remnant liver for 3 days after 50% hepatectomy or sham operation. Total hepatic oxygen consumption (HV o 2 ) per liver weight, hepatic oxygen extraction ratio (H o 2 ER), and DNA synthesis were significantly elevated at days 1 and 3 after hepatectomy, compared with the preoperative levels. Meanwhile, significantly decreased Shv o 2 levels were observed at days 1 and 3, and the Shvo 2 levels were significantly correlated with the HV o 2 . Furthermore, the decreased Shv o 2 levels were synchronized with the increased DNA synthesis in the remnant liver. Energy charge levels were also significantly decreased at day 1 after hepatectomy. These results suggest that the regenerating liver demands an increased amount of oxygen for mitochondrial oxidative phosphorylation to restore hepatic energy charge. In conclusion, the Shv o 2 after hepatectomy may reflect oxygen metabolic status in the remnant liver and could be useful for estimating liver regeneration.