Research Library

Premium Intestinal absorption and enterohepatic cycling of biliary iron originating from plasma non‐transferrin‐bound iron in rats
Brissot P,
Bolder U,
Schteingart C D,
Arnaud J,
Hofmann A F
Publication year1997
Publication title
Resource typeJournals
PublisherWiley Subscription Services
Abstract In iron overload, non‐transferrin‐bound iron (NTBI) is found in plasma and is rapidly removed by hepatocytes. Some of this NTBI is excreted into bile. Biliary excretion of NTBI, in the form of an iron‐ deferiprone chelate, is greatly increased by deferiprone, an iron chelator. The aim of this study was to test whether biliary iron as such or as an iron‐deferiprone chelate (both originating from plasma NTBI) is absorbed from the intestine and re‐secreted into bile. In healthy biliary fistula (donor) rats, biliary 55 Fe originating from plasma NTBI was obtained by injecting Fe citrate (to saturate transferrin) followed by 55 Fe. This biliary 55 Fe was infused into the duodenum of (recipient) rats whose transferrin was saturated or unsaturated. Similar experiments were performed using iron‐overloaded (donor) rats given deferiprone, followed by infusion of the biliary 55 Fe‐deferiprone chelate into iron‐overloaded (recipient) rats. The results show that in healthy (recipient) rats, duodenal infusion of 55 Fe from NTBI was followed by increased plasma 55 Fe when transferrin was unsaturated, or by biliary excretion of 55 Fe when transferrin was saturated, indicating intestinal absorption of 55 Fe. In iron‐overloaded rats, neither plasma nor bile became radioactive, indicating no intestinal absorption of iron from the deferiprone chelate. We conclude that biliary iron, originating from NTBI, is absorbed from the intestine, and undergoes enterohepatic circulation if transferrin is saturated. In iron‐overloaded rats, biliary iron originating from plasma NTBI and present as an iron‐deferiprone chelate in bile is not absorbed.
Subject(s)bile acid , biochemistry , chelation , chemistry , deferiprone , deferoxamine , duodenum , endocrinology , enterohepatic circulation , inorganic chemistry , medicine , transferrin
SCImago Journal Rank5.488

Seeing content that should not be on Zendy? Contact us.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here