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Immune response to cyclin B1 in hepatocellular carcinoma
Author(s) -
Covini G.,
Chan E. K.,
Nishioka M.,
Morshed S. A.,
Reed S. I.,
Tan E. M.
Publication year - 1997
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.510250114
Subject(s) - cyclin b1 , cyclin a , cyclin e1 , cyclin d , cyclin a2 , cyclin b , cyclin d1 , autoantibody , cyclin , cancer research , cyclin e , cyclin dependent kinase , biology , hepatocellular carcinoma , antibody , microbiology and biotechnology , cyclin dependent kinase 1 , cell cycle , immunology , biochemistry , cell
Proteins expressed by plasmids encoding human cyclins and cyclin‐dependent kinase 2 (CDK2) were used as antigens in immunoblotting. Fifteen of 100 patients with hepatocellular carcinoma (HCC) were found to have autoantibodies reactive with cyclin B1 and with a 40‐kd degradation product of cyclin B1‐glutathione‐S‐transferase (GST) fusion protein. Only one serum was found to react with cyclin A and another single serum with CDK2 but no antibodies were detected to cyclin D1 and E. The basis for autoimmune responses to cyclin B1 in HCC are unknown at the present time but the possibilities might include aberrations in cyclin B1 regulation leading to altered product or its expression which resulted in stimulation of immune reactions.