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Long‐term administration of isosorbide‐5‐mononitrate does not impair renal function in cirrhotic patients
Author(s) -
Salerno F,
Borroni G,
Lorenzano E,
Solenghi D,
Cazzaniga M,
Bissoli F,
Ceriani R,
deFranchis R
Publication year - 1996
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.510230530
Subject(s) - renal function , medicine , ascites , plasma renin activity , urine , excretion , cirrhosis , blood pressure , gastroenterology , urology , endocrinology , renin–angiotensin system
Isosorbide‐5‐mononitrate (Is‐5‐Mn), alone or combined with β‐ blockers, has been proposed for prophylaxis of variceal bleeding in cirrhosis. However, renal insufficiency, might be an important undesirable effect of this therapy, especially in patients with ascites. We assessed the changes in renal function induced in 26 cirrhotic patients by acute or chronic administration of Is‐5‐Mn. The acute administration of 20 mg of Is‐5‐Mn to 21 patients reduced mean blood pressure (83.4 ± 2.4 vs. 92.8 ± 3.4 mm Hg, P < .001), urine volume (5.5 ± 0.8 vs. 8.7 ± 1.1 mL/min, P < .05), urine sodium excretion (114 ± 19 vs. 244 ± 41 muEq/min, P < .001), urine potassium excretion (41 ± 3.4 vs. 67 ± 8.5 muEq/min, P < .001), and atrial natriuretic factor (74 ± 10 vs. 98 ± 12 pg/mL, P < .005). The glomerular filtration rate was decreased in the 11 patients with ascites (57 ± 9 vs. 68 ± 12 mL/min, P < .05), and plasma renin activity was increased in 4 ascitics. Twenty‐one patients (16 from the acute study + 5 other patients) were given Is‐5‐Mn for 3 months at the dose of 80 mg/d. This did not affect blood pressure and renal function in patients without ascites, but reduced mean blood pressure (91.9 ± 3.4 vs. 89.6 ± 3 mm Hg, P < .05), urine volume (5.8 ± 1.1 vs. 3.4 ± 0.9 mL/min, P < .05), and urine sodium excretion (205 ± 38 vs. 99 ± 16 muEq/min, P < .01) in those with ascites. There were no changes in glomerular filtration rate and renal plasma flow, while plasma renin activity increased in only 3 patients with ascites and 1 without. Systemic hemodynamics and renal function of cirrhotic patients, especially those with ascites, are affected adversely by acute administration of Is‐5‐Mn. Long‐term administration of the drug is well tolerated by compensated patients and does not affect renal plasma flow nor glomerular filtration rate, but can induce hypotension and sodium retention in patients with ascites.