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Inhibition of 5‐lipoxygenase promotes the regeneration of the liver after partial hepatectomy in normal and icteric rats
Author(s) -
Urade M,
Izumi R,
Kitagawa H
Publication year - 1996
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.510230320
Subject(s) - hepatectomy , liver regeneration , medicine , gastroenterology , jaundice , bilirubin , pharmacology , surgery , regeneration (biology) , biology , resection , microbiology and biotechnology
The role of leukotriene (LT) on liver regeneration after hepatectomy is still unknown. LTB 4 stagnates in the liver with obstructive jaundice, because LTB 4 is excreted in the bile; therefore, LTB 4 may have an effect on liver regeneration after hepatectomy with obstructive jaundice. Release of obstructive jaundice and simultaneous 70% hepatectomy was performed in rats to study the effect of 5‐lipoxygenase inhibitor (AA‐861) on liver regeneration. Group 1 underwent hepatectomy with administration of 0.1 mL dimethyl sulfoxide (DMSO), group 2 underwent hepatectomy with administration of AA‐861 (20 mg/kg/d) dissolved in 0.1 mL DMSO, group 3 underwent hepatectomy with administration of AA‐861 (40 mg/kg/d) dissolved in 0.1 mL DMSO, group 4 underwent release of obstructive jaundice and hepatectomy with administration of 0.1 mL DMSO, and group 5 underwent relief of obstructive jaundice and hepatectomy with administration of AA‐861 (20 mg/kg/d). DMSO or AA‐861 was administered 24 hours before, during, and 24 hours after hepatectomy in each group. Whole blood LTB 4 and serum alanine aminotransferase (ALT), total bilirubin, and bromodeoxyuridine labeling index (LI) were measured before and after hepatectomy. The LTB 4 level increased during obstructive jaundice and after hepatectomy. LTB 4 and serum ALT levels were significantly lower after hepatectomy in the rats that were administered AA‐861, and a significantly higher LI was observed at 24 hours after hepatectomy in rats receiving AA‐861. Inhibition of 5‐lipoxygenase promotes liver regeneration and decreases hepatocyte injury after hepatectomy associated with obstructive jaundice.