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Liver Diseases in the Perinatal Period: Interactions Between Mother and Infant
Author(s) -
Ibrahim Samar H.,
Jonas Maureen M.,
Taylor Sarah A.,
Gutierrez Sanchez Luz Helena,
Wolf Jaqueline L.,
Sundaram Shikha S.
Publication year - 2020
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.31109
Subject(s) - pregnancy , medicine , offspring , gestation , acute fatty liver of pregnancy , fetus , gestational period , liver disease , nonalcoholic fatty liver disease , gestational diabetes , presentation (obstetrics) , cholestasis , pediatrics , fatty liver , disease , obstetrics , biology , genetics
Liver diseases affecting the mother and infant dyad may present in the perinatal period from 20 weeks of gestation to 28 days of life. This review will focus on the current approach to neonatal acute liver failure and the progress made in the diagnosis and management of gestational alloimmune liver disease. It will highlight mother‐to‐child transmission of viral hepatitis, both management and public health implications. Emerging concepts implicating maternal obesity and nutrition in the development of a rapidly progressive nonalcoholic steatohepatitis phenotype in the offspring will be discussed. Finally, the presentation and management of acute fatty liver of pregnancy and intrahepatic cholestasis of pregnancy, and their impact on the fetus, will be reviewed.