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Improved posttransplant mortality after share 35 for liver transplantation
Author(s) -
Kwong Allison J.,
Goel Aparna,
Mannalithara Ajitha,
Kim W. Ray
Publication year - 2018
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.29301
Subject(s) - medicine , united network for organ sharing , liver transplantation , hazard ratio , liver disease , proportional hazards model , transplantation , model for end stage liver disease , decompensation , fulminant hepatic failure , cirrhosis , confidence interval , survival analysis , surgery , gastroenterology
The Share 35 policy was implemented in June 2013 to improve equity in access to liver transplantation (LT) between patients with fulminant liver failure and those with cirrhosis and severe hepatic decompensation. The aim of this study was to assess post‐LT outcomes after Share 35. Relevant donor, procurement, and recipient data were extracted from the Organ Procurement and Transplantation Network/United Network for Organ Sharing database. All adult deceased donor LTs from January 1, 2010, to March 31, 2016, were included in the analysis. One‐year patient survival before and after Share 35 was assessed by multivariable Cox proportional hazards analysis, with adjustment for variables known to affect graft survival. Of 34,975 adult LT recipients, 16,472 (47.1%) were transplanted after the implementation of Share 35, of whom 4,599 (27.9%) had a Model for End‐Stage Liver Disease (MELD) score ≥35. One‐year patient survival improved from 83.9% to 88.4% after Share 35 ( P < 0.01) for patients with MELD ≥35. There was no significant impact on survival of patients with MELD <35 ( P = 0.69). Quality of donor organs, as measured by a donor risk index without the regional share component, improved for patients with MELD ≥35 ( P < 0.01) and worsened for patients with lower MELD ( P < 0.01). In multivariable Cox regression analysis, Share 35 was associated with improved 1‐year patient survival (hazard ratio, 0.69; 95% confidence interval, 0.60‐0.80) in recipients with MELD ≥35. Conclusion: Share 35 has had a positive impact on survival after transplantation in patients with MELD ≥35, without a reciprocal detriment in patients with lower acuity; this was in part a result of more favorable donor–recipient matching. (H epatology 2018;67:273‐281).