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Fecal microbiota transplantation induces hepatitis B virus e‐antigen (HBeAg) clearance in patients with positive HBeAg after long‐term antiviral therapy
Author(s) -
Ren YanDan,
Ye ZhenShi,
Yang LiuZhu,
Jin LiXin,
Wei WenJun,
Deng YongYue,
Chen XiaoXiao,
Xiao ChuanXing,
Yu XiaoFang,
Xu HongZhi,
Xu LiZhu,
Tang YunNa,
Zhou Fei,
Wang XueLian,
Chen MeiYa,
Chen LiGang,
Hong MeiZhu,
Ren JianLin,
Pan JinShui
Publication year - 2017
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.29008
Subject(s) - virology , hbeag , medicine , antiviral therapy , fecal bacteriotherapy , virus , chronic hepatitis , hepatitis b virus , biology , microbiology and biotechnology , hbsag , antibiotics , clostridium difficile
对于HBeAg阳性慢性乙型肝炎慢乙肝患者而言HBeAg血清学转换是重要的治疗目标也是停药的先决条件之一。但核苷酸类似物治疗时仅有少部分患者可实现HBeAg清除或血清学转换率。随着对肠-肝轴认识的深入人们已发现肠道微生物在慢性肝病的发生发展中都扮演了一定角色。从这个角度出发该研究设计了一项病例对照、开放标签的前导性研究探索了粪菌移植Fecal microbiota TransplantationFMT在长期NA治疗后HBeAg仍未转阴的慢乙肝患者中的治疗价值。该研究成果对慢性乙型肝炎尤其是难以停药患者的临床处理策略具有重要启发意义。【Abstract】For hepatitis B virus (HBV) e-antigen (HBeAg)-positive chronic hepatitis B (CHB)patients, HBeAg seroconversion is a prerequisite for a definite course of antiviral
treatment. Unfortunately, for both entecavir (ETV) and tenofovir disoproxil
fumarate (TDF), HBeAg clearance or seroconversion only occurs in a minority of
patients even after multiple years of antiviral therapy. The gut microbiota
appears to play a critical role in age-related immune clearance of HBV.Several
studies have indicated that CHB patients with liver cirrhosis have different
microbiota compared to healthy people.The “leakage hypothesis” has linked
gut microbiota to the onset and progression of liver diseases. Thus, we
reported a case controlled, open-label pilot trial of fecal microbiota
transplantation (FMT) for CHB patients.The study was funded by the National Science Foundation for Young Scholars,China (No. 81100285), and the Key Foundation of Health System for Young Talents of Fujian (No.2013-ZQN-ZD-33)