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A Karnofsky performance status–based score predicts death after hospital discharge in patients with cirrhosis
Author(s) -
Tandon Puneeta,
Reddy K. Rajender,
O'Leary Jacqueline G.,
GarciaTsao Guadalupe,
Abraldes Juan G.,
Wong Florence,
Biggins Scott W.,
Maliakkal Benedict,
Fallon Michael B.,
Subramanian Ram M.,
Thuluvath Paul,
Kamath Patrick S.,
Thacker Leroy R.,
Bajaj Jasmohan S.
Publication year - 2017
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.28900
Subject(s) - medicine , performance status , cirrhosis , hospital discharge , karnofsky performance status , emergency medicine , patient discharge , medline , overall survival , political science , law
Identification of patients with cirrhosis at risk for death within 3 months of discharge from the hospital is essential to individualize postdischarge plans. The objective of the study was to identify an easy‐to‐use prognostic model based on the Karnofsky Performance Status (KPS). The North American Consortium for the Study of End‐Stage Liver Disease consists of 16 tertiary‐care hepatology centers that prospectively enroll nonelectively admitted cirrhosis patients. Patients enrolled had KPS assessed 1 week postdischarge. KPS was categorized into low (score 10‐40), intermediate (50‐70), and high (80‐100). Of 954 middle‐aged patients (57 ± 10 years, 63% men) with a median Model for End‐Stage Liver Disease (MELD) score of 17 (interquartile range 13‐21), the mortality rates for the low, intermediate, and high performance status groups were 23% (36/159), 11% (55/489), and 5% (15/306), respectively. Low, intermediate, and high performance status was seen in 17%, 51%, and 32% of the cohort, respectively. Low performance status was associated with older age, dialysis, hepatic encephalopathy, longer length of stay, and higher white blood cell count or MELD score at discharge. A model was derived using the three independent predictors of 3‐month mortality: KPS, age, and MELD score. This score had better discrimination (area under the receiver operating characteristic curve = 0.74) than a model using MELD (area under the receiver operating characteristic curve = 0.62) or MELD and age (area under the receiver operating characteristic curve = 0.67) to predict 3‐month mortality. Conclusions : Cirrhosis patients at risk for 3‐month postdischarge mortality can be identified using a novel KPS‐based score; this score may be adopted in practice to guide postdischarge early interventions, including the integrated provision of active and palliative management strategies. (H epatology 2017;65:217‐224).