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Liver X receptors and copper metabolism: New frontiers for the oxysterol receptors
Author(s) -
Gabbi Chiara,
Bertolotti Marco
Publication year - 2016
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.28534
Subject(s) - liver x receptor , farnesoid x receptor , oxysterol , nuclear receptor , liver x receptor alpha , small heterodimer partner , receptor , pregnane x receptor , medicine , chemistry , agonist , biology , endocrinology , microbiology and biotechnology , biochemistry , cholesterol , gene , transcription factor
Treatment with Liver X Receptor (LXR) agonists ameliorates disease manifestation in a mouse model of Wilson disease (WD) but only with a partial effect in inducing the predicted LXR target genes. These studies open new perspective for the oxysterols recptors LXR, involved not only in controlling lipid metabolism, inflammation, water transport and cell proliferation but also in regulating copper homeostasis