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Author(s) -
McLaren Christine E.,
Barton James C.,
Subramaniam V. Nathan,
Ramm Grant A.,
Phatak Pradyumna D.,
Emond Mary J.,
Gurrin Lyle C.,
Adams Paul C.,
Powell Lawrie W.,
Anderson Gregory J.,
McLaren Gordon D.
Publication year - 2016
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.28479
Subject(s) - hepcidin , transferrin saturation , medicine , ethics committee , gynecology , endocrinology , gastroenterology , iron deficiency , political science , anemia , public administration
We read with interest the report by Hsiao et al. that\udTaiwanese women not selected for iron phenotypes,\udwho were hetero- or homozygous for the glycerone-\udphosphate O-acyltransferase (GNPAT) p.D519G\ud(rs11558492) polymorphism, had higher serum iron\udlevels than GNPAT wild-type subjects. Women with\udGNPAT p.D519G also had higher levels of serum iron\udand transferrin saturation (TS) after a test dose of oral iron. Response to oral iron was not signicantly differ-\udent in Taiwanese women with or without TMPRSS6\udrs855791, a polymorphism associated with reduced\udactivity of the enzyme, matriptase-2, an inhibitor of\udhepcidin transcription