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Poster Session 3: Adaptive and Innate Immunology; Alcohol: Clinical and Experimental
Author(s) -
Jeffery, HC,
Van Wilgenburg, B,
Stirling, K,
Parekh, K,
Roberts, S,
Kurioka, A,
Hunter, S,
Adams, DH,
Klenerman, P,
Oo, YH
Publication year - 2015
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.28229
Subject(s) - session (web analytics) , immunology , medicine , clinical immunology , computer science , world wide web , allergy
Mucosal-Associated Invariant T (MAIT) cells are unconventional T-cells characterised by the invariant T-cell antigen receptor α-chain, Vα7.2, high expression of CD161 and restriction by the MHC class 1-related molecule, MR1. They are important for antibacterial immunity at mucosal sites; however, their role in the pathogenesis of hepatic inflammation remains unclear. Here we investigated the frequency, phenotype, localisation and function of liver infiltrating (LI) MAIT cells