Premium
Hepatic lipid droplet biology: Getting to the root of fatty liver
Author(s) -
Mashek Douglas G.,
Khan Salmaan A.,
Sathyanarayan Aishwarya,
Ploeger Jonathan M.,
Franklin Mallory P.
Publication year - 2015
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.27839
Subject(s) - organelle , steatosis , lipid droplet , lipid metabolism , function (biology) , fatty liver , biology , microbiology and biotechnology , biochemistry , chemistry , medicine , endocrinology , disease
Hepatic steatosis is defined by the accumulation of lipid droplets (LDs). Once thought to be only inert energy storage depots, LDs are increasingly recognized as organelles that have important functions in hepatocytes beyond lipid storage. The lipid and protein composition of LDs is highly dynamic and influences their intrinsic metabolism and signaling properties, which ultimately links them to the changes in hepatic function. This concise review highlights recent discoveries in LD biology and unique aspects of hepatic LDs and their role in liver disease. (H epatology 2015;62:964–967)