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Tenofovir‐associated Fanconi syndrome and nephrotic syndrome in a patient with chronic hepatitis B monoinfection
Author(s) -
Hwang Hyeon Seok,
Park Cheol Whee,
Song Myeong Jun
Publication year - 2015
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.27730
Subject(s) - fanconi syndrome , tenofovir , nephrotic syndrome , medicine , chronic hepatitis , hepatitis b , gastroenterology , virology , immunology , human immunodeficiency virus (hiv) , kidney , virus
Tenofovir disoproxil fumarate (TDF) is widely used as an effective first‐line therapy for chronic hepatitis B (CHB) infection. While TDF demonstrates successful viral suppression, it has been linked to the development of renal proximal tubular (PT) dysfunction, leading to Fanconi syndrome. However, Fanconi syndrome has been rarely reported in CHB‐monoinfected patients, and there were no reports of TDF‐associated nephrotic syndrome. Here, we report a case of combined Fanconi and nephrotic syndrome in CHB patients after TDF exposure. (H epatology 2015;62:1318‐1320)