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Modulating the activation of hepatic stellate cells: A cunning way for metastatic cells to create a permissive soil for seeding in the liver?
Author(s) -
Coulouarn Cédric
Publication year - 2015
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.27330
Subject(s) - intravasation , metastasis , primary tumor , hepatic stellate cell , tumor microenvironment , cancer cell , pathology , colorectal cancer , medicine , cancer , cancer research , hepatocellular carcinoma , circulating tumor cell , biology
International audienceHepatocellular carcinoma (HCC) is the most frequent type of primary cancer in the liver. However, far more common than HCC are liver metastases. Indeed, the liver is one of the most frequent sites of implantation of metastatic tumor cells originating from skin, colon and breast primary cancers