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Peritransplant absolute lymphocyte count as a predictive factor for advanced recurrence of hepatitis C after liver transplantation
Author(s) -
Nagai Shunji,
Yoshida Atsushi,
Kohno Keisuke,
Altshuler David,
Nakamura Mio,
Brown Kimberly A.,
Abouljoud Marwan S.,
Moonka Dilip
Publication year - 2014
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.26536
Subject(s) - medicine , immunosuppression , hazard ratio , gastroenterology , liver transplantation , proportional hazards model , lymphocyte , hepatitis c virus , hepatitis c , risk factor , globulin , fibrosis , multivariate analysis , immunology , transplantation , confidence interval , virus
Lymphocytes play an active role in natural immunity against hepatitis C virus (HCV). We hypothesized that a lower absolute lymphocyte count (ALC) may alter HCV outcome after liver transplantation (LT). The aim of this study was to investigate the impact of peritransplant ALC on HCV recurrence following LT. A total of 289 LT patients between 2005 and 2011 were evaluated. Peritransplant ALC (pre‐LT, 2‐week, and 1‐month post‐LT) and immunosuppression were analyzed along with recipient and donor factors in order to determine risk factors for HCV recurrence based on METAVIR fibrosis score. When stratifying patients according to pre‐ and post‐LT ALC (<500/μL versus 500‐1,000/μL versus >1,000/μL), lymphopenia was significantly associated with higher rates of HCV recurrence with fibrosis (F2‐4). Multivariate Cox regression analysis showed posttransplant ALC at 1 month remained an independent predictive factor for recurrence ( P = 0.02, hazard ratio [HR] = 2.47 for <500/μL). When peritransplant ALC was persistently low (<500/μL pre‐LT, 2‐week, and 1‐month post‐LT), patients were at significant risk of developing early advanced fibrosis secondary to HCV recurrence (F3‐4 within 2 years) ( P = 0.02, HR = 3.16). Furthermore, severe pretransplant lymphopenia (<500/μL) was an independent prognostic factor for overall survival ( P = 0.01, HR = 3.01). The use of rabbit anti‐thymocyte globulin induction (RATG) had a remarkable protective effect on HCV recurrence ( P = 0.02, HR = 0.6) despite its potential to induce lymphopenia. Subgroup analysis indicated that negative effects of posttransplant lymphopenia at 1 month (<1,000/μL) were significant regardless of RATG use and the protective effects of RATG were independent of posttransplant lymphopenia. Conclusion : Peritransplant ALC is a novel and useful surrogate marker for prediction of HCV recurrence and patient survival. Immunosuppression protocols and peritransplant management should be scrutinized depending on peritransplant ALC. (H epatology 2014;58:35–45)