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Emerging role of fibroblast growth factors 15/19 and 21 as metabolic integrators in the liver
Author(s) -
Cicione Claudia,
Degirolamo Chiara,
Moschetta Antonio
Publication year - 2012
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.25929
Subject(s) - fgf21 , fibroblast growth factor , hormone , subfamily , biology , druggability , growth hormone , insulin , endocrine system , microbiology and biotechnology , metabolic regulation , endocrinology , biochemistry , metabolism , receptor , gene
Fibroblast growth factors (FGFs) 15/19 and 21 belong to the FGF endocrine subfamily. They present the intriguing characteristic to be transcribed and secreted in certain tissues and to act as hormones. The insulin‐mimetic properties of FGF21 and the regulatory role of FGF15/19 in bile acid and glucose homeostasis endorse these hormones as druggable targets in metabolic disorders. Here, we present details on discoveries, identification, transcriptional regulation, and mechanism of actions of FGF15/19 and FGF21 with a critical perspective view on their putative role as metabolic integrators in the liver. (H EPATOLOGY 2012;56:2404–2411)