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Long noncoding RNA associated with microvascular invasion in hepatocellular carcinoma promotes angiogenesis and serves as a predictor for hepatocellular carcinoma patients' poor recurrence‐free survival after hepatectomy
Author(s) -
Yuan ShengXian,
Yang Fu,
Yang Yuan,
Tao QiFei,
Zhang Jin,
Huang Gang,
Yang Yun,
Wang RuoYu,
Yang Sen,
Huo XiSong,
Zhang Ling,
Wang Fang,
Sun ShuHan,
Zhou WeiPing
Publication year - 2012
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.25895
Subject(s) - angiogenesis , hepatocellular carcinoma , metastasis , medicine , cancer research , hepatectomy , carcinoma , oncology , long non coding rna , cancer , biology , rna , gene , surgery , biochemistry , resection
Abstract Survival of patients with hepatocellular carcinoma (HCC) remains poor, which is largely attributed to active angiogenesis. However, the mechanisms underlying angiogenesis in HCC remain to be discovered. In this study, we found that long noncoding RNA associated with microvascular invasion in HCC (lncRNA MVIH) (lncRNA associated with microvascular invasion in HCC) was generally overexpressed in HCC. In a cohort of 215 HCC patients, the overexpression of MVIH was associated with frequent microvascular invasion ( P = 0.016) and a higher tumor node metastasis stage ( P = 0.009) as well as decreased recurrence‐free survival (RFS) ( P < 0.001) and overall survival ( P = 0.007). Moreover, the up‐regulation of MVIH served as an independent risk factor to predict poor RFS. We also found that MVIH could promote tumor growth and intrahepatic metastasis by activating angiogenesis in mouse models. Subsequent investigations indicated that MVIH could activate tumor‐inducing angiogenesis by inhibiting the secretion of phosphoglycerate kinase 1 (PGK1). Additionally, in 65 HCC samples, MVIH expression was inversely correlated with the serum level of PGK1 and positively correlated with the microvessel density. Conclusion : Deregulation of lncRNA MVIH is a predictor for poor RFS of HCC patients after hepatectomy and could be utilized as a potential target for new adjuvant therapies against active angiogenesis. (H EPATOLOGY 2012;56:2142–2153)