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Risk factors for cholangiocarcinoma
Author(s) -
Tyson Gia L.,
ElSerag Hashem B.
Publication year - 2011
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.24351
Subject(s) - primary sclerosing cholangitis , hepatolithiasis , medicine , hepatocellular carcinoma , gastroenterology , malignancy , cirrhosis , hepatology , hepatitis b virus , risk factor , intrahepatic cholangiocarcinoma , disease , virus , immunology , surgery , hepatectomy , resection
Cholangiocarcinoma (CC) is the second most common primary hepatic malignancy after hepatocellular cancer. CC accounts for approximately 10%‐25% of all hepatobiliary malignancies. There are considerable geographic and demographic variations in the incidence of CC. There are several established risk factors for CC, including parasitic infections, primary sclerosing cholangitis, biliary‐duct cysts, hepatolithiasis, and toxins. Other less‐established potential risk factors include inflammatory bowel disease, hepatitis C virus, hepatitis B virus, cirrhosis, diabetes, obesity, alcohol drinking, tobacco smoking, and host genetic polymorphisms. In studies where the distinction between intra‐ and extrahepatic CC was used, some potential risk factors seem to have a differential effect on CC, depending on the site. Therefore, the consistent use of a more refined classification would allow a better understanding of risk factors for CC. (H EPATOLOGY 2011;)