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Drug‐induced cholestasis
Author(s) -
Padda Manmeet S.,
Sanchez Mayra,
Akhtar Abbasi J.,
Boyer James L.
Publication year - 2011
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.24229
Subject(s) - cholestasis , drug , medicine , mechanism (biology) , computational biology , intensive care medicine , bioinformatics , pharmacology , gastroenterology , biology , philosophy , epistemology
Recent progress in understanding the molecular mechanisms of bile formation and cholestasis have led to new insights into the pathogenesis of drug‐induced cholestasis. This review summarizes their variable clinical presentations, examines the role of transport proteins in hepatic drug clearance and toxicity, and addresses the increasing importance of genetic determinants, as well as practical aspects of diagnosis and management. (H EPATOLOGY 2011;)