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Role of leisure‐time physical activity in nonalcoholic fatty liver disease: A population‐based study
Author(s) -
ZelberSagi Shira,
NitzanKaluski Dorit,
Goldsmith Rebecca,
Webb Muriel,
Zvibel Izabel,
Goldiner Ilana,
Blendis Laurie,
Halpern Zamir,
Oren Ran
Publication year - 2008
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.22525
Subject(s) - medicine , nonalcoholic fatty liver disease , adiponectin , fatty liver , odds ratio , resistin , body mass index , insulin resistance , population , anthropometry , confidence interval , gastroenterology , obesity , disease , environmental health
Physical activity (PA) is commonly recommended for nonalchoholic fatty liver disease (NAFLD) patients. However, there is limited evidence on the independent role of PA in NAFLD. The aim of this study was to examine the association between PA and NAFLD. We conducted a cross‐sectional study of a subsample (n = 375) of the Israeli National Health and Nutrition Survey. Exclusion criteria were any known etiology for liver disease. Participants underwent an abdominal ultrasound examination; biochemical tests, including leptin, adiponectin, and resistin; and the noninvasive biomarker SteatoTest and anthropometric evaluations. A semiquantitative food frequency questionnaire and a detailed PA questionnaire were administered. Three hundred forty‐nine patients (52.7% men, 30.9% primary NAFLD) were included. The NAFLD group engaged in less aerobic, resistance, or other kinds of PA ( P ≤ 0.03). The SteatoTest was significantly lower among subjects engaging in any PA or resistance PA at least once a week ( P ≤ 0.01). PA at least once a week in all categories was associated with a reduced risk for abdominal obesity. Adjusting for sex, engaging in any kind of sports (odds ratio [OR] 0.66, 95% confidence interval [CI] 0.44‐0.96 per 1 standard deviation increment in PA score) and resistance exercise (OR 0.61, 95% CI 0.38‐0.85) were inversely associated with NAFLD. These associations remained unchanged after adjusting for homeostasis model assessment, most nutritional factors, adiponectin, and resistin. Only the association with resistance PA remained significant with further adjustment for body mass index (OR 0.61, 95% CI 0.44‐0.85). Adding leptin or waist circumference to the model eliminated the statistical significance. Conclusion: Habitual leisure‐time PA, especially anaerobic, may play a protective role in NAFLD. This association appears to be mediated by a reduced rate of abdominal obesity. (H EPATOLOGY 2008;48:1791‐1798.)