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Increased mediastinal fat and impaired left ventricular energy metabolism in young men with newly found fatty liver
Author(s) -
Perseghin Gianluca,
Lattuada Guido,
De Cobelli Francesco,
Esposito Antonio,
Belloni Elena,
Ntali Georgia,
Ragogna Francesca,
Canu Tamara,
Scifo Paola,
Del Maschio Alessandro,
Luzi Livio
Publication year - 2008
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.21983
Subject(s) - medicine , endocrinology , fatty liver , phosphocreatine , adipose tissue , fatty acid , insulin resistance , fatty acid metabolism , biology , insulin , metabolism , energy metabolism , biochemistry , disease
Fatty liver is characterized by metabolic abnormalities at the liver, but also at skeletal muscle and adipose tissue sites. It is hypothesized that the heart may be suffering metabolic alterations, and this study was undertaken to ascertain whether individuals with fatty liver have left ventricular (LV) alterations of energy metabolism, structure, and function and abnormal amounts of epicardial fat as a specific marker of visceral fat accumulation. To this end we studied young, nondiabetic men matched for anthropometric features with (n = 21) or without (n = 21) fatty liver by means of (1) cardiac magnetic resonance imaging (MRI); (2) cardiac 31 P‐MR spectroscopy (MRS); and (3) hepatic 1 H‐MRS to assess quantitatively the intrahepatic fat (IHF) content. Insulin sensitivity was determined by the updated HOMA‐2 computer model. Individuals with fatty liver showed reduced insulin sensitivity, increased serum free fatty acid (FFA), and E‐selectin, abnormal adipokine concentrations, and higher blood pressure. LV morphology and systolic and diastolic functions were not different; however, in the scanned intrathoracic region, the intrapericardial (7.8 ± 3.1 versus 5.9 ± 2.5 cm 2 ; P < 0.05) and extrapericardial (11.7 ± 6.1 versus 7.8 ± 3.2 cm 2 ; P < 0.03) fat was increased in men with fatty liver compared with those without fatty liver. The phosphocreatine (PCr)/adenosine triphosphate (ATP) ratio, a recognized in vivo marker of myocardial energy metabolism, was reduced in men with fatty liver in comparison with normals (1.85 ± 0.35 versus 2.11 ± 0.31; P < 0.016). In conclusion, in newly found individuals with fatty liver, fat was accumulated in the epicardial area and despite normal LV morphological features and systolic and diastolic functions, they had abnormal LV energy metabolism. (H EPATOLOGY 2008.)