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Nuclear factor‐κB and the hepatic inflammation‐fibrosis‐cancer axis
Author(s) -
Elsharkawy Ahmed M.,
Mann Derek A.
Publication year - 2007
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.21802
Subject(s) - inflammation , fibrosis , multicellular organism , biology , liver cancer , cancer research , hepatocellular carcinoma , hepatic fibrosis , immune system , immunology , medicine , cell , pathology , genetics
Abstract Nuclear factor‐κB (NF‐κB) is a transcriptional regulator of genes involved in immunity, inflammatory response, cell fate, and function. Recent attention has focused on the pathophysiological role of NF‐κB in the diseased liver. In vivo studies using rodent models of liver disease and cell‐targeted perturbation of NF‐κB activity have revealed complex and multicellular functions in hepatic inflammation, fibrosis, and the development of hepatocellular carcinoma—a process we have termed the “inflammation‐fibrosis‐cancer axis”. This review summarizes the current state of knowledge and provides insight into the vast complexity of the hepatic NF‐κB signaling system, which should provide a rich source of new therapeutic targets. (H EPATOLOGY 2007;46:590–597.)