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Maid (GCIP) is involved in cell cycle control of hepatocytes
Author(s) -
SonnenbergRiethmacher Eva,
Wüstefeld Torsten,
Miehe Michaela,
Trautwein Christian,
Riethmacher Dieter
Publication year - 2007
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.21461
Subject(s) - cell cycle , biology , dna synthesis , cell cycle progression , embryonic stem cell , cancer research , microbiology and biotechnology , cell , dna , gene , genetics
Abstract The function of Maid (GCIP), a cyclinD‐binding helix‐loop‐helix protein, was analyzed by targeted disruption in mice. We show that Maid function is not required for normal embryonic development. However, older Maid‐deficient mice—in contrast to wild‐type controls—develop hepatocellular carcinomas. Therefore, we studied the role of Maid during cell cycle progression after partial hepatectomy (PH). Lack of Maid expression after PH was associated with a delay in G1/S‐phase progression as evidenced by delayed cyclinA expression and DNA replication in Maid‐deficient mice. However, at later time points liver mass was restored normally. Conclusion: These results indicate that Maid is involved in G1/S‐phase progression of hepatocytes, which in older animals is associated with the development of liver tumors. (H EPATOLOGY 2007;45:404–411.)