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Genomics and complex liver disease: Challenges and opportunities
Author(s) -
Juran Brian D.,
Lazaridis Konstantinos N.
Publication year - 2006
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.21453
Subject(s) - disease , genomics , human genetic variation , genome wide association study , complex disease , genetic predisposition , liver disease , human genome , hepatology , biology , bioinformatics , genetics , genotype , medicine , genome , single nucleotide polymorphism , gene , pathology , biochemistry
The concept of genetic susceptibility in the contribution to human disease is not new. What is new is the emerging ability of the field of genomics to detect, assess, and interpret genetic variation in the study of susceptibility to development of disease. Deciphering the human genome sequence and the publication of the human haplotype map are key elements of this effort. However, we are only beginning to understand the contribution of genetic predisposition to complex liver disease through its interaction with environmental risk factors. In the coming decade, we anticipate the development of human studies to better dissect the genotype/phenotype relationship of complex liver diseases. This endeavor will require large, well‐phenotyped patient populations of each disease of interest and proper study designs aimed at answering important questions of hepatic disease prognosis, pathogenesis, and treatment. Teamwork between patients, physicians, and genomics scientists can ensure that this opportunity leads to important biological discoveries and improved treatment of complex disease. (H EPATOLOGY 2006;44:1380–1390.)

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