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Liver biopsy interpretation for causes of late liver allograft dysfunction
Author(s) -
Demetris A. J.
Publication year - 2006
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.21280
Subject(s) - medicine , liver transplantation , primary biliary cirrhosis , primary sclerosing cholangitis , liver biopsy , differential diagnosis , autoimmune hepatitis , serology , pathology , biopsy , cirrhosis , viral hepatitis , gastroenterology , transplantation , disease , immunology , antibody
Evaluation of needle biopsies and extensive clinicopathological correlation play an important role in the determination of liver allograft dysfunction occurring more than 1 year after transplantation. Interpretation of these biopsies can be quite difficult because of the high incidence of recurrent diseases that show histopathological, clinical, and serological features that overlap with each other and with rejection. Also, more than one insult can contribute to allograft injury. In an attempt to enable centers to compare and pool results, improve therapy, and better understand pathophysiological disease mechanisms, the Banff Working Group on Liver Allograft Pathology herein proposes a set of consensus criteria for the most common and problematic causes of late liver allograft dysfunction, including late‐onset acute and chronic rejection, recurrent and new‐onset viral and autoimmune hepatitis, biliary strictures, and recurrent primary biliary cirrhosis and primary sclerosing cholangitis. A discussion of differential diagnosis is also presented. (H EPATOLOGY 2006;44:489–501.)