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Aquaporins in the hepatobiliary system
Author(s) -
Masyuk Anatoliy I.,
LaRusso Nicholas F.
Publication year - 2006
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.20996
Subject(s) - aquaporin , biology , secretion , aquaporin 1 , water channel , microbiology and biotechnology , endocrinology , mechanical engineering , engineering , inlet
The review focuses on the potential physiological and pathophysiological roles of aquaporins (AQPs), a family of water channel proteins, in the hepatobiliary system. Among 13 aquaporins (AQP0‐AQP12) cloned in mammals, seven AQPs have been identified in the liver and biliary tree. Accumulating evidence suggests that AQPs are likely involved in canalicular and ductal bile secretion, gluconeogenesis and microbial infection and may have other novel roles that affect liver function. (H epatology 2006;43:S75–S81.)