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Transforming growth factor β can mediate apoptosis via the expression of TRAIL in human hepatoma cells
Author(s) -
Herzer Kerstin,
Ganten Tom M.,
SchulzeBergkamen Henning,
GrosseWilde Anne,
Koschny Ronald,
Krammer Peter H.,
Walczak Henning
Publication year - 2005
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.20757
Subject(s) - apoptosis , microbiology and biotechnology , transforming growth factor , expression (computer science) , cancer research , factor (programming language) , biology , genetics , computer science , programming language
Transforming growth factor β (TGF‐β) has been shown to induce apoptotic cell death in normal and transformed hepatocytes. However, the exact mechanism through which TGF‐β induces cell death is still unknown. We examined a potential role of various death receptor/ligand systems in TGF‐β–induced apoptosis and identified the tumor necrosis factor–related apoptosis‐inducing ligand (TRAIL) as a mediator of TGF‐β–induced apoptosis in hepatoma cells. TGF‐β–induced apoptosis is significantly impaired upon blockage of TRAIL. We show that TRAIL is upregulated in hepatoma cells upon treatment with TGF‐β, whereas TRAIL receptor levels remain unchanged. In conclusion , our results provide evidence that the TRAIL system is critically involved in TGF‐β–induced cell death in liver pathology. (H EPATOLOGY 2005;42:183–192.)