Telomeres and telomerase: A dual role in hepatocarcinogenesis | Zendy

Satyanarayana Ande | Zendy; Manns Michael P. | Zendy; Rudolph K. Lenhard | Zendy

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Telomeres and telomerase: A dual role in hepatocarcinogenesis

Author(s) -

Satyanarayana Ande,

Manns Michael P.,

Rudolph K. Lenhard

Publication year - 2004

Publication title -

hepatology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.488

H-Index - 361

eISSN - 1527-3350

pISSN - 0270-9139

DOI - 10.1002/hep.20308

Subject(s) - telomere , telomerase , dual (grammatical number) , telomerase rna component , cancer research , biology , computational biology , medicine , genetics , telomerase reverse transcriptase , dna , art , gene , literature

Telomere shortening limits the proliferative capacity of primary human cells and restrains the regenerative capacity of organ systems during chronic diseases and aging. Telomere shortening apparently has a dual role in tumor development and progression. On the one hand, it induces chromosomal instability and the initiation of cancer; on the other hand, tumor progression requires stabilization of telomeres. The predominant mechanism of telomere stabilization in tumor cells is the activation of the telomere‐synthesizing enzyme telomerase. The potential use of telomerase activators for the treatment of regenerative disorders will ultimately depend on their effects on tumorigenesis. This review focuses on the role of telomere shortening and telomerase in carcinogenesis with a special focus on hepatocellular carcinoma. (H EPATOLOGY 2004;40:276–283.)

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