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Interfering with capsid formation: A practicable antiviral strategy against hepatitis B virus?
Author(s) -
Kann Michael
Publication year - 2004
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.20144
Subject(s) - adefovir , virology , hepatitis b virus , medicine , interferon , virus , capsid , antiviral drug , combination therapy , in vivo , antiviral therapy , hepatitis c virus , lamivudine , immunology , chronic hepatitis , biology , pharmacology , microbiology and biotechnology
Chronic hepatitis B virus (HBV) infection is a major cause of liver disease. Only interferon-alpha and the nucleosidic inhibitors of the viral polymerase, 3TC and adefovir, are approved for therapy. However, these therapies are limited by the side effects of interferon and the substantial resistance of the virus to nucleosidic inhibitors. Potent new antiviral compounds suitable for monotherapy or combination therapy are highly desired. We describe nonnucleosidic inhibitors of HBV nucleocapsid maturation that possess in vitro and in vivo antiviral activity. These inhibitors have potential for future therapeutic regimens to combat chronic HBV infection.