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Octreotide blunts postprandial splanchnic hyperemia in cirrhotic patients: A double‐blind randomized echo‐doppler study
Author(s) -
Buonamico Paolo,
Sabbá Carlo,
GarciaTsao Guadalupe,
Berardi Elsa,
Antonica Gianfranco,
Ferraioli Giovanna,
Jensen Jonathan E.,
Lerner Emanuel,
Taylor Kenneth J. W.,
Albano Ottavio,
Groszmann Roberto J.
Publication year - 1995
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840210123
Subject(s) - medicine , postprandial , splanchnic , octreotide , splanchnic circulation , cardiology , radiology , blood flow , somatostatin , insulin
The effect of octreotide, a long‐acting synthetic analog of somatostatin, on fasting and postprandial splanchnic hemodynamics was investigated in cirrhotic patients. Splanchnic hemodynamics were assessed using an echo–Doppler duplex system in a prospective, double‐blind, placebo‐controlled, crossover study performed on 2 separate days, 1 week apart, in 30 cirrhotic patients. Measurements of portal vein (PV) cross‐sectional area (PV‐A) and mean velocity (PV‐V), and of superior mesenteric artery (SMA) mean velocity (SMA‐V) and pulsatility index (SMA‐PI) (an index of vascular resistance) were performed at baseline, 30 minutes after octreotide (200 μg subcutaneously) or placebo administration, and 30 and 60 minutes after the ingestion of a liquid meal. In the fasted state, octreotide induced a significant decrease in PV‐V (–7%) and in SMA–V (–10%) and an increase in PI (+16%). On the day of placebo administration, meal ingestion induced a significant increase in PV‐V (+21%). and in SMA‐V (+43%) and a decrease in PI (–21%). In contrast, meal ingestion on octreotide day induced significantly smaller increases in PV‐V (+10%) and in SMA‐V (+18%) and a significantly smaller decrease in PI (–10%). Octreotide, although producing a mild reduction in PV‐V and SMA‐V in the fasted state, markedly blunts postprandial splanchnic hyperemia in cirrhotic patients. (Hepatology 1995;21:134‐139).