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What's wrong when it isn't right: Situs inversus and genetic control of organ position
Author(s) -
Fishman Laurie N.,
Lavine Joel E.
Publication year - 1994
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840190138
Subject(s) - situs inversus , biology , transgene , mutation , genetically modified mouse , genetics , gene , anatomy
Abstract A recessive mutation was identified in a family of transgenic mice that resulted in a reversal of left‐right polarity (situs inversus) in 100 percent of the homozygous transgenic mice tested. Sequences that flanked the transgenic integration site were cloned and mapped to mouse chromosome 4, between the Tsha and Hxb loci. During early embryonic development, the direction of postimplantation turning, one of the earliest manifestations of left‐right asymmetry, was reversed in homozygous transgenic embryos. This insertional mutation identifies a gene that controls embryonic turning and visceral left‐right polarity.