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Transjugular intrahepatic portosystemic shunt worsens the hyperdynamic circulatory state of the cirrhotic patient: Preliminary report of a prospective study
Author(s) -
Azoulay D.,
Castaing D.,
Dennison A.,
Martino W.,
Eyraud D.,
Bismuth H.
Publication year - 1994
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840190121
Subject(s) - transjugular intrahepatic portosystemic shunt , hyperdynamic circulation , medicine , circulatory system , cardiology , portal hypertension , shunt (medical) , cirrhosis
The aim of this prospective nonrandomized study was to assess the immediate and short‐term sequelae of transjugular intrahepatic portosystemic shunting on the circulatory hyperdynamic state of the cirrhotic patient. Twelve transjugular portosystemic shunting procedures were performed in 12 cirrhotic patients for sclerotherapy failure (10 cases) and/or intractable ascites (4 cases). Self‐expandable stents 10 mm in diameter were used in all cases. Portal pressure measurement and right‐heart catheterization were performed before and 30 min and 1 mo after the procedure. The portoatrial pressure gradient decreased from 15 ± 3 to 7 ± 3 mm Hg 30 min after surgery (p < 0.0001) to 8 ± 3 mm Hg 1 mo after surgery (p < 0.001, in comparison with basal values). The cardiac index increased from 4.5 ± 1.3 to 5.7 ± 1.5 L/min·m 2 30 min after surgery (p < 0.001) to 7.4 ± 1.4 L/min μ 2 1 mo after surgery (p < 0.001). Systemic vascular resistance decreased from 808 ± 323 to 646 ± 209 dyne·sec·cm −5 30 min after surgery (p < 0.01) to 467 ± 101 dyne·sec·cm −5 1 mo after surgery (p < 0.05). This study demonstrates that transjugular portosystemic shunting rapidly and significantly worsens the hyperdynamic circulatory state of the cirrhotic patient. Although apparently noninvasive, this procedure should be considered with caution in cirrhotic patients with limited cardiac reserve. (Hepatology 1994;19:129–132).