Premium
Evidence for neurological dysfunction in end‐stage protoporphyric liver disease
Author(s) -
Rank Jeffrey M.,
Carithers Robert,
Bloomer Joseph
Publication year - 1993
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840180619
Subject(s) - ferrochelatase , erythropoietic protoporphyria , medicine , protoporphyrin , gastroenterology , vomiting , nausea , abdominal pain , liver transplantation , transplantation , liver disease , pathology , anesthesia , heme , biochemistry , chemistry , porphyrin , photochemistry , enzyme
Protoporphyria is a genetic disorder characterized by a defect in the enzyme ferrochelatase, which catalyzes the chelation of iron to protoporphyrin. This causes excessive accumulation and excretion of protoporphyrin. The predominant clinical feature is photosensitivity. Progressive and fatal liver disease occurs in a small percentage of cases. We report our experience with eight patients with end‐stage protoporphyric liver disease in whom a syndrome developed before transplantation that resembled the neurological crises of the acute porphyrias. This syndrome was characterized by abdominal pain, hypertension, tachycardia, extremity pain and weakness, constipation and nausea and vomiting. Erythrocyte and serum protoporphyrin levels were markedly increased in all patients. In one patient, profound hemolysis developed during the anhepatic phase of transplantation and continued over a period of 72 hr, causing an extreme increase in the serum protoporphyrin level. Progressive weakness deteriorated to paralysis in this patient. This phenomenon suggests that protoporphyrin may gain access to neural tissue when serum levels are markedly increased, causing neurotoxicity. (HEPATOLOGY 1993;18:1404–1409.)